Houston Cardiovascular Associates Houston Cardiovascular Associates

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Amifostine Injection

(am'' i fos' teen)

Brand Name(s): Ethyol®

Other Name(s): Ethiofos

WHY is this medicine prescribed?

Amifostine is used protect the kidneys from harmful effects of the chemotherapy drug cisplatin in patients that receive this medication for the treatment of ovarian cancer. Amifostine is also used to decrease dryness in the mouth caused by radiation treatment after surgery for head and neck cancer. Amifostine is in a class of medications called cytoprotectants. It works by protecting against the harmful effects of chemotherapy medications and radiation treatment.

Are there OTHER USES for this medicine?

Amifostine is also sometimes used to prevent and decrease side effects associated with certain chemotherapy medications or radiation treatment and in the treatment of some types of blood cell diseases.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Amifostine comes as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. When amifostine is used to protect the kidneys against the harmful effects of cisplatin, it is usually given over 15 minutes starting 30 minutes before you receive your chemotherapy treatment. When amifostine is used to reduce the severe dry mouth caused by radiation treatment, it is usually given over 3 minutes starting 15–30 minutes before your radiation treatment.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

What SPECIAL PRECAUTIONS should I follow?

Before receiving amifostine,

  • tell your doctor and pharmacist if you are allergic to amifostine, any other medications, or any of the ingredients in amifostine injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention medications for high blood pressure. Your doctor will tell you to stop taking your blood pressure medicine 24 hours before you receive amifostine injection. Many other medications may also interact with amifostine, so be sure to tell your doctor about all the medications you are taking.

  • tell your doctor if you have or have ever had heart disease, an irregular heartbeat, heart failure, or a stroke or ministroke.

  • tell your doctor if you are pregnant or plan to become pregnant, or are breast-feeding. If you become pregnant while receiving amifostine, call your doctor. You should not breast-feed during your treatment with amifostine.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Amifostine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • flushing or feeling of warmth
  • chills or feeling of coldness
  • general feeling of tiredness
  • fever
  • drowsiness
  • sneezing
  • hiccups

Some side effects can be serious. If you experience any of these symptoms , call your doctor immediately:

  • shortness of breath
  • dizziness
  • blurred vision
  • fainting
  • seizures
  • chest tightness
  • chest pain
  • rash
  • hives
  • itching
  • difficulty breathing or swallowing
  • peeling or blistering skin
  • fast, slow, or pounding heartbeat

Amifostine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • dizziness
  • lightheadedness
  • fainting

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to amifostine.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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Dear patient

I am excited to announce that I will be relocating my practice to Houston Methodist DeBakey Cardiology Associates. Starting November 4, 2024, my new address will be:

Houston Methodist DeBakey Cardiology Associates
6550 Fannin St.
Smith Tower, Suite 1901
Houston, TX 77030

Please note that my phone number and fax number will also change to the following:
24-Hour Telephone: 713-441-1100
Fax: 713-790-2643
Clinical Support Telephone (M-F, 8-5): 713-441-3515

I am excited about caring for you in my new office and hope you will make the transition with me. I will also continue to refill your medications as I have in the past. To assist, please provide your pharmacy with my new contact information.

Please consider checking your prescription refills to verify that you have enough medication on hand to last you until your next visit. Please note that your medical records will remain at my former office until you authorize their transfer. If you choose for me to continue providing your medical care, please complete and sign the enclosed “Authorization for Release of Medical Records” form and fax it to 713-790-2643. Once we receive your authorization, we will be happy to process the request for you.

Thank you for entrusting me with your medical care. My new team and I are dedicated to making this transition as seamless as possible. For help scheduling an appointment and transitioning your care, please call my new office number above.

I look forward to continuing your care at my new location.

Sincerely,
Gopi A. Shah, MD

Dear patient

Dr. Albert Raizner, Dr. Michael Raizner, and Dr. Mohamed El-Beheary are excited to announce that our practice, Interventional Cardiology Associates, will merge with Houston Cardiovascular Associates on November 1, 2024.

Our new offices are similarly located in Houston, near the Texas Medical Center and in Sugar Land. Our in-hospital care will continue at Houston Methodist Hospital in the Texas Medical Center and Houston Methodist Sugar Land Hospital. Importantly, our new offices expand our services with state-of-the-art equipment and amenities. Our core values will always be, as they began over 40 years ago when Dr. Albert Raizner founded ICA:

Integrity – Compassion – Accountability

Our new address and contact information are:

Your medical records are confidential and remain available at our new locations. We consider it a privilege to serve as your cardiologists and look forward to your continuing with us. However, should you desire to transfer to another physician, you may request a copy of your records by contacting us at our new addresses and phone numbers listed above.

We thank you for your trust and loyalty. As always, we will continue to be here to take care of you. Please do not hesitate to contact us if you have any questions or concerns.

Sincerely,

Dr. Albert Raizner,
Dr. Michael Raizner,
Dr. Mohamed El-Beheary